Essays in Contemporary Chemistry

Essays in Contemporary Chemistry

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In this volume, internationally renowned chemists recount their roles in the progress of chemistry research toward elucidation of biological processes. Beginning with a historical perspective on the development of Xa€“ray crystallography, the reader is regaled with firsta€“hand accounts of research milestones. Included are descriptions of the cuttinga€“edge nucleara€“magnetica€“resonance and electrona€“paramagnetica€“resonance spectroscopic techniques, the dynamics of ultraa€“fast reactions, and the central problem of molecular oxygen activation in biological processes. The roles of chiral auxiliaries in organic synthesis and of photochemistry in natural product synthesis are told, and innovations in combinatorial synthesis approaches are described. Contemporary issues in molecular recognition and modulation of molecular function are addressed, concluding with a missive regarding how the frontiers of medical ethics may be breached by molecular manipulations. The contributors, who number among the finest scientists in the world, including two Nobel Prize winners, are Peter B. Dervan, Jack D. Dunitz, Christian Griesinger, Jeana€“Marie Lehn, Thomas F. Prisner, Gerhard Quinkert, Peter G. Schultz, Helmut Schwarz, Dieter Seebach, and Ahmed Zewail. Additionally, there is a prologue by Albert Eschenmoser, for whom this collection was conceived, and an epilogue that contains facsimiles of notes from his landmark lecture a€²Synthesis of Coa€“Enzyme B12: A Vehicle for Teaching Organic Synthesisa€². This book is definitely a must for all who want to read, or to read again, where we stand in our chemical comprehension of the fascinating relationship between chemical structure and biological processes, how we got here, and what the future might hold.S Acyl shift (1st. step in protein splicing) aqueous buffer pH7.0 Fig. 57. Chemical ligation for the reduction of the number of resonances in a protein. Synthesis of, e.g., the N-terminal part of the protein using 13C- andlsN-labelling. and of theanbsp;...


Title:Essays in Contemporary Chemistry
Author: Gerhard Quinkert, M. Volkan Kisakürek
Publisher:John Wiley & Sons - 2001
ISBN-13:

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